2720. Cyclofenil

Nomenclature

CAS number: 2624-43-3
4-[[4-(Acetyloxy)phenyl]cyclohexylidenemethyl]phenol acetate; α-cyclohexylidene-α-(p-hydroxyphenyl)-p-cresol diacetate; bis(p-acetoxyphenyl)cyclohexylidenemethane; 4,4′-diacetoxybenzhydrylidenecyclohexane; F-6066; H-3452; ICI-48213; Fertodur (Schering AG); Neoclym (Poli); Ondogyne (Roussel Diamant); Rehibin (Thames); Sanocrisin (Ferrosan); Sexovid (Ferrosan).
C23H24O4; mol wt 364.43.
C 75.80%, H 6.64%, O 17.56%.

Description and references

Prepn: Miquel et al., J. Med. Chem. 6, 774 (1963); Olsson et al., US 3287397 (1966). Pharmacology: Hiramatsu et al., Oyo Yakuri 6, 1045 (1972), C.A. 78, 131963z (1973).

Chemical structure

Properties

Crystals from ethanol, mp 135-136°. uv max (ethanol): 247 nm (ε 17000).

Derivative

Free diol.

Nomenclature

F-6060.
C19H20O2; mol wt 280.36.
C 81.40%, H 7.19%, O 11.41%.

Properties

mp 235-236°.

Therapeutic Category

Gonad-stimulating principle.

Keywords

Gonad-Stimulating Principle