2923. Deslorelin

Nomenclature

CAS number: 57773-65-6
6-d-Tryptophan-9-(N-ethyl-l-prolinamide)-1-9-luteinizing hormone-releasing factor (swine); [d-Trp6,des-Gly10]-LH-RH ethylamide.
C64H83N17O12; mol wt 1282.45.
C 59.94%, H 6.52%, N 18.57%, O 14.97%.

Description and references

Synthetic nonapeptide agonist analog of LH-RH, q.v. Prepn: D. H. Coy et al., J. Med. Chem. 19, 423 (1976); W. Kornreich et al., Int. J. Pept. Protein Res. 25, 414 (1985). Pharmacology: K. Sundaram et al., Life Sci. 28, 83 (1981). Pharmacokinetics and metabolism: B. Candas et al., J. Clin. Endocrinol. Metab. 70, 1046 (1990). Clinical inhibition of spermatogenesis: R. Linde et al., N. Engl. J. Med. 305, 663 (1981). Clinical evaluation in precocious puberty: J. A. Yanovski et al., N. Engl. J. Med. 348, 908 (2003). Induction of ovulation in mares: V. J. Farquhar et al., J. Equine Vet. Sci. 20, 722 (2000). Review of veterinary use in control of reproduction: T. E. Trigg et al., Theriogenology 66, 1507-1512 (2006).

Chemical structure

Properties

[α]D24 -61° (c = 0.37 in 0.1M acetic acid).

Derivative

Acetate.

Nomenclature

CAS number: 82318-06-7
Ovuplant (Wyeth Animal Health); Suprelorin (Peptech).
C64H83N17O12.C2H4O2; mol wt 1342.50.
C 59.05%, H 6.53%, N 17.74%, O 16.68%.

Therapeutic Category (Veterinary)

For induction of ovulation in mares; canine male contraceptive.