3102. DIDS
Nomenclature
CAS number: 53005-05-3
2,2′-(1,2-Ethenediyl)bis[5-isothiocyanatobenzenesulfonic acid]; 4,4′-diisothiocyanato-2,2′-stilbenedisulfonic acid. C16H10N2O6S4; mol wt 454.52.
C 42.28%, H 2.22%, N 6.16%, O 21.12%, S 28.22%.
Description and references
Classic inhibitor of ion transport across biological membranes. Prepn: Z. I. Cabantchik, A. Rothstein, J. Membr. Biol. 10, 311 (1972); of tritated form: S. Ship et al., ibid. 33, 311 (1977). Inhibition of chloride transport: T. Janas et al., Am. J. Physiol. 257, C601 (1989); J.-A. Kim et al., Biochem. Biophys. Res. Commun. 309, 291 (2003); of non-selective cation conductance: A. Diakov et al., Pfluegers Arch. 442, 700 (2001). Effects of ionic strength and pH on membrane penetration: V. A. Tverdislov et al., Colloids Surf. B 5, 205 (1995). Mechanism of inhibition in erythrocytes: J. M. Salhany, Blood Cells Mol. Dis. 27, 901 (2001); of cardiac ryanodine receptor: A. P. Hill, R. Sitsapesan, Biophys. J. 82, 3037 (2002).
