3291. Diopterin

Nomenclature

CAS number: 6807-82-5
N-[N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-l-α-glutamyl]-l-glutamic acid; pteroyl-α-glutamylglutamic acid; pteroyldiglutamic acid; PDGA.
C24H26N8O9; mol wt 570.51.
C 50.53%, H 4.59%, N 19.64%, O 25.24%.

Description and references

Folic acid analog. Synthesis: Mowat et al., J. Am. Chem. Soc. 70, 1096 (1948); Hutchings, and Geraci, US 2500825 and US 2501168 (both 1950 to Am. Cyanamid); Geraci, US 2766240 (1956 to Aries Labs.).

Chemical structure

Properties

Precipitate from hot water. Sol in dil NaOH solns.