3363. Disufenton
Nomenclature
CAS number: 168021-77-0
4-[[(1,1-Dimethylethyl)oxidoimino]methyl]-1,3-benzenedisulfonic
acid; 2,4-disulfonyl-α-phenyl-tert-butylnitrone. C11H15NO7S2; mol wt 337.37.
C 39.16%, H 4.48%, N 4.15%, O 33.20%, S 19.01%.
Description and references
Nitrone-based spin trapping agent; derivative of PBN, q.v. Prepn: J. M. Carney, WO 9517876; idem, US 5488145 (1995, 1996 both to Oklahoma Med. Res. Found.). Pharmacology: S. Kuroda et al., J. Cereb. Blood Flow Metab. 19, 778 (1999). Comparative radical trapping study: K. R. Maples et al., Free Radical Res. 34, 417 (2001). Clinical pharmacokinetics: K. R. Lees et al., Stroke 32, 675 (2001). Clinical trial in acute ischemic stroke: idem et al., N. Engl. J. Med. 354, 588 (2006). Reviews of pharmacology and therapeutic potential: P. A. Lapchak, Curr. Opin. Investig. Drugs 3, 1758-1762 (2002); P. A. Lapchak, D. M. Araujo, CNS Drug Rev. 9, 253-262 (2003).
Properties
White powder. Soly (g/ml): water >1.Derivative
Sodium salt.Nomenclature
CAS number: 168021-79-2
Disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide; ARL-16556; CPI-22; CXY-059; NXY-059; Cerovive (AstraZeneca). C11H13NNa2O7S2; mol wt 381.33.
C 34.65%, H 3.44%, N 3.67%, Na 12.06%, O 29.37%, S 16.82%.
Therapeutic Category
Neuroprotective.
Keywords
Neuroprotective