3365. Disulfoton

Nomenclature

CAS number: 298-04-4
Phosphorodithioic acid O,O-diethyl S-[2-(ethylthio)ethyl] ester; O,O-diethyl-S-ethylmercaptoethyl dithiophosphate; thiodemeton; dithiodemeton; Bay 19639; ENT-23347; Baysiston (Bayer CropSci.); Di-Syston (Bayer CropSci.).
C8H19O2PS3; mol wt 274.40.
C 35.02%, H 6.98%, O 11.66%, P 11.29%, S 35.06%.

Description and references

Organophosphate insecticide; cholinesterase inhibitor. Homolog of phorate, q.v. Prepn: Schrader, Lorenz, US 2759010; GB 797307 (1956, 1958 both to Bayer). GC/MS determn in water samples: P.-S. Chen, S.-D. Huang, Talanta 69, 669 (2006) DOI PubMed. Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969) DOI PubMed. Review of toxicology and human exposure: Toxicological Profile for Disulfoton (PB95-264347, 1995) 239 pp.

Chemical structure

Properties

Colorless oil, bp0.01 108°, bp1.5 132-133°. d420 1.144. nD20 1.5348. Vapor pressure at 20°: 1.8 × 10-4 mm Hg. Insol in water. Poisonous. LD50 in female, male rats (mg/kg): 2.3, 6.8 orally; 6, 15 dermally (Gaines).

Caution

Potential symptoms of overexposure are irritation of eyes, skin; nausea, vomiting, abdominal cramps, diarrhea, salivation; headache, giddiness, vertigo, weakness; rhinorrhea, chest tightness; blurred vision, miosis; cardiac irregularity; muscle fasciculations; dyspnea; eye and skin burns. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 124.

Use

Acaricide; insecticide.