3414. Domiodol
Nomenclature
CAS number: 61869-07-6
2-(Iodomethyl)-1,3-dioxolane-4-methanol; 4-hydroxymethyl-2-iodomethyl-1,3-dioxolane; MG-13608; Mucolitico (Maggioni). C5H9IO3; mol wt 244.03.
C 24.61%, H 3.72%, I 52.00%, O 19.67%.
Description and references
Organic iodide mixture of cis and trans isomers. Prepn: M. Carissimi et al., DE 2610704; eidem, US 4085223 (1976, 1978 both to Maggioni). Prepn, expectorant and mucolytic activities: G. Cantarelli et al., Farmaco Ed. Prat. 34, 393 (1979). Pharmacology, toxicity: K. Kogi et al., Arzneim.-Forsch. 33, 1281 (1983). Separation of isomers and comparison of their pharmacological activity: M. Riva et al., ibid. 1091. Metabolism and tissue distribution in rats: T. Ohtsuki et al., Farmaco Ed. Prat. 39, 291 (1984). Comparative study with S-carboxymethylcysteine, q.v., in chronic obstructive lung disease: L. Casali et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 554 (1982).
Properties
LD50 in male, female mice (mg/kg): 79, 89 i.p.; 140, 145 orally (Riva).Derivative
cis-Form.Properties
bp0.2 106-108°. LD50 orally in male mice: 135 mg/kg (Riva).Derivative
trans-Form.Properties
bp0.2 114-116°. LD50 orally in male mice: 150 mg/kg (Riva).Therapeutic Category
Mucolytic.
Keywords
Mucolytic