3523. Efloxate

Nomenclature

CAS number: 119-41-5
[(4-Oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]acetic acid ethyl ester; 7-flavone ethyl hydroxyacetate; ethyl flavon-7-yloxyacetate; ethyl 7-flavonoxyacetate; 7-flavonoxyacetic acid ethyl ester; oxyflavil; Re-1-0185; Recordil (Recordati).
C19H16O5; mol wt 324.33.
C 70.36%, H 4.97%, O 24.67%.

Description and references

Prepn: P. Da Re et al., Farmaco Ed. Sci. 13, 561 (1958); GB 803372 and GB 824547 (1958, 1959 both to Recordati); P. Da Re, A. Colleoni, Ann. Chim. (Rome) 49, 1632 (1959).

Chemical structure

Properties

Crystals from 50% ethanol, mp 123-124°. Soluble in the usual organic solvents; slightly sol in water. LD50 i.p. in rats: 3200 mg/kg (Da Re).

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)