3756. Ethybenztropine

Nomenclature

CAS number: 524-83-4
(3-endo-)-3-(Diphenylmethoxy)-8-ethyl-8-azabicyclo[3.2.1]octane; 3α-(diphenylmethoxy)-8-ethyl-1αH,5αH-nortropane; N-ethylnortropine benzhydryl ether; tropethydrylin; N-ethyl-8-aza-3-bicyclo[3.2.1]octyl benzhydryl ether; N-ethylbenztropine; ethylbenzatropine; etybenzatropine.
C22H27NO; mol wt 321.46.
C 82.20%, H 8.47%, N 4.36%, O 4.98%.

Description and references

Anticholinergic. Prepn: GB 804837 (1958 to Sandoz); Boehringer et al., GB 824875 (1959 to Boehringer, Ing.).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 26598-44-7
Ponalide (Novartis).
C22H27NO.HCl; mol wt 357.92.
C 73.83%, H 7.89%, N 3.91%, O 4.47%, Cl 9.91%.

Properties

Crystals from acetone, mp 190-191°.

Derivative

Hydrobromide.

Nomenclature

CAS number: 24815-25-6
C22H27NO.HBr; mol wt 402.37.
C 65.67%, H 7.01%, N 3.48%, O 3.98%, Br 19.86%.

Properties

Crystals from methanol + ether, mp 226-228°.

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian; Antimuscarinic