3872. Etiroxate

Nomenclature

CAS number: 17365-01-4
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-dl-tyrosine ethyl ester; dl-α-methylthyroxine ethyl ester; CG-635.
C18H17I4NO4; mol wt 818.95.
C 26.40%, H 2.09%, I 61.98%, N 1.71%, O 7.81%.

Description and references

Deriv of thyroxine, q.v. Prepn: NL 6614150; H. Kummer, R. Beckmann, US 3930017 (1967, 1975 both to Grünenthal). Animal studies: R. Beckmann, Arzneim.-Forsch. 29, 499 (1979). Effect on iodine metabolism in man: D. Emrich, ibid. 27, 422 (1977). Use in hyperlipoproteinemia: H. Banz, F. P. Gall, Fortschr. Med. 97, 1942 (1979); eidem, Med. Klin. 75, 51 (1980).

Chemical structure

Properties

Cryst from ethanol, mp 156-157°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 55327-22-5
Skleronorm (Grünenthal).
C18H17I4NO4.HCl; mol wt 855.41.
C 25.27%, H 2.12%, I 59.34%, N 1.64%, O 7.48%, Cl 4.14%.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Thyroid Hormones/Analogs