3878. Etofylline

Nomenclature

CAS number: 519-37-9
3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-hydroxyethyl)theophylline; oxyethyltheophylline; Oxytheonyl; Oxphylline (Amido); Phyllocormin N.
C9H12N4O3; mol wt 224.22.
C 48.21%, H 5.39%, N 24.99%, O 21.41%.

Description and references

Obtained by the action of glycol monochlorohydrin upon theophylline in an alkaline medium: Lespagnol et al., Bull. Soc. Pharm. Lille 1948, no. 2, p 18; Roth, Arch. Pharm. 292, 234 (1959); Fabbrini, Cencioni, Farmaco Ed. Sci. 17, 660 (1962).

Chemical structure

Properties

Crystals from abs ethanol, mp 158°. Freely sol in water. Moderately sol in alcohol. pH of a 5% aq soln 6.5-7.0. Solns may be sterilized by heating. Pharmacological action as of theophylline.

Therapeutic Category

Bronchodilator.

Keywords

Bronchodilator; Xanthine Derivatives