3879. Etofylline Nicotinate

Nomenclature

CAS number: 13425-39-3
3-Pyridinecarboxylic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester; nicotinic acid ester with 7-(2-hydroxyethyl)theophylline; 7-(2-hydroxyethyl)theophylline nicotinate; Hesotanol; Hesotin.
C15H15N5O4; mol wt 329.31.
C 54.71%, H 4.59%, N 21.27%, O 19.43%.

Description and references

Prepn: Pongratz, Zirm, Monatsh. Chem. 88, 330 (1957). Pharmacology: Fischbach, Haas, Arzneim.-Forsch. 17, 313 (1967).

Chemical structure

Properties

Fine dendritic needles from abs alcohol, mp 151-152°. Hydrated crystals from water. One gram dissolves in 50 ml boiling water; moderately sol in alcohol.

Therapeutic Category

Vasodilator.