3877. Etofibrate

Nomenclature

CAS number: 31637-97-5
3-Pyridinecarboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl ester; nicotinic acid 2-hydroxyethyl ester 2-(p-chlorophenoxy)-2-methylpropionate (ester); ethylene glycol 1-[2-(p-chlorophenoxy)-2-methylpropionate]-2-nicotinate; α-[(p-chlorophenoxy)isobutyroyl]-β-(nicotinoyl)glycol; ethofibrate; Lipo-Merz (Merz).
C18H18ClNO5; mol wt 363.79.
C 59.43%, H 4.99%, Cl 9.75%, N 3.85%, O 21.99%.

Description and references

Glycol diester of nicotinic and clofibric acids, q.q.v. Prepn: A. Scherm, D. Peteri, DE 1941217; eidem, US 3723446 (1971, 1973 both to Merz). Lipid lowering effects in rats: W. Sterner, A. Schultz, Arzneim.-Forsch. 24, 1990 (1974). Metabolism: H. Oelschl"ager et al., ibid. 30, 984 (1980). In vitro effect on human platelet function: M. P. Ortega et al., Thromb. Res. 19, 409 (1980). HPLC determn in plasma: E. R. Garrett, M. R. Gardner, J. Pharm. Sci. 71, 14 (1982). Bioavailability and pharmacokinetics in humans: K. I. Johnson et al., Arzneim.-Forsch. 34, 1785 (1984). Review of pharmacology and comparison with other hypolipidemic agents: R. Paoletti et al., Am. J. Cardiol. 52, Suppl B, 21B-27B (1983).

Chemical structure

Properties

Crystalline powder, mp 100°.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates