3880. Etoglucid

Nomenclature

CAS number: 1954-28-5
2,2′-(2,5,8,11-Tetraoxadodecane-1,12-diyl)bisoxirane; 1,2:15,16-diepoxy-4,7,10,13-tetraoxahexadecane; 1,2-bis[2-(2,3-epoxypropoxy)ethoxy]ethane; triethylene glycol diglycidyl ether; TDE; ethoglucid; ICI-32865; Epodyl (Ayerst).
C12H22O6; mol wt 262.30.
C 54.95%, H 8.45%, O 36.60%.

Description and references

Prepn: Greenshields et al., GB 901876 (1962 to ICI); Blyakhman, Zh. Org. Khim. 3, 1423 (1967), C.A. 68, 59384k (1968); X.-P. Gu et al., Synthesis 1985, 649. Pharmacology and metabolism: Duncan, Snow, Biochem. J. 82, 8P (1962); James, Solheim, Xenobiotica 1, 43 (1971). Clinical evaluation in bladder tumors: M. R. G. Robinson et al., J. Urol. 118, 972 (1977); J. Flamm, F. Grof, Urologe B27, 26 (1987).

Chemical structure

Properties

Colorless liquid, mp -15 to -11°. bp0.005 140°; bp0.1 133-149°; bp2 195-197°. d20 1.1312. nD20 1.4584.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents