3945. Febarbamate

Nomenclature

CAS number: 13246-02-1
1-[2-[(Aminocarbonyl)oxy]-3-butoxypropyl]-5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 1-(3-butoxy-2-hydroxypropyl)-5-ethyl-5-phenylbarbituric acid carbamate; 1-(3-butoxy-2-carbamoyloxypropyl)-5-phenyl-5-ethylbarbituric acid; G"o-560; G-Tril; Tymium (Sapos).
C20H27N3O6; mol wt 405.44.
C 59.25%, H 6.71%, N 10.36%, O 23.68%.

Description and references

Prepn: P. Gold-Aubert, E. Gysin, Helv. Chim. Acta 44, 105 (1961); P. Gold-Aubert, US 3075983 (1963 to Sapos). Pharmacology: E. Frommel et al., Helv. Physiol. Pharmacol. Acta 19, 241 (1961). Metabolism in rats: J. Vachta, P. Gold-Aubert, Eur. J. Drug Metab. Pharmacokinet. 7, 147 (1982); in man: J. Vachta et al., ibid. 8, 297 (1983).

Chemical structure

Properties

Syrup; could not be crystallized, dec ≈196°. Sol in alcohol, dioxane. Insol in water. LD50 orally in mice: 1065 mg/kg (Frommel).

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Barbituric Acid Derivatives