3951. Felbinac

Nomenclature

CAS number: 5728-52-9
(1,1′-Biphenyl)-4-acetic acid; 4-biphenylacetic acid; 4-carboxymethylbiphenyl; BPAA; LY-61017; L-141; LJC-10141; Napageln (Lederle); Traxam (Lederle).
C14H12O2; mol wt 212.24.
C 79.23%, H 5.70%, O 15.08%.

Description and references

One of the metabolites of fenbufen, q.v. Prepn: E. Schwenk, D. Papa, J. Org. Chem. 11, 798 (1946). Improved prepn: G. R. Malone, A. I. Meyers, ibid. 39, 618 (1974). Pharmacology: A. E. Sloboda, A. C. Osterberg, Inflammation 1, 415 (1976). Mode of action study in ocular inflammation: E. L. Tolman et al., Invest. Ophthalmol. 15, 1005 (1976). HPLC determn in serum: J. S. Fleitman et al., J. Chromatogr. 228, 372 (1982).

Chemical structure

Properties

White needles from ethyl ether, mp 164-165°. LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg).

Derivative

Ethyl ester.

Nomenclature

CAS number: 14062-23-8
LM-001; Daitec (Lederle).
C16H16O2; mol wt 240.30.
C 79.97%, H 6.71%, O 13.32%.

Therapeutic Category

Anti-inflammatory, analgesic.

Keywords

Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives; Analgesic; Non-opioids; Acetic/Propionic Acid Derivatives