4064. Ferumoxsil

Nomenclature

CAS number: 171544-35-7
AMI-121; GastroMARK (Mallinckrodt); Lumiren (Guerbet).

Description and references

Active ingredient of colloidal super paramagnetic iron oxide (SPIO) consisting of nonstoichiometric magnetite cores coated with siloxane (FeOx[C3H13N2SiO2]y); designed for use as negative MRI contrast agent. Prepn: M. S. Chagnon et al., EP 125995, R. A. Whitehead et al., US 4554088 (1984, 1985 both to Advanced Magnetics). Physical and chemical properties: C. W. Jung, P. Jacobs, Magn. Reson. Imaging 13, 661 (1995). Surface properties: C. W. Jung, ibid. 675. Clinical study in lower abdominal imaging: R. C. H. Heusler et al., J. Magn. Reson. Imaging 4, 385 (1995); A. D'Arienzo et al., Am. J. Gastroenterol. 95, 720 (2000).

Properties

Aqueous suspension, turbid, slightly viscous, dark brown to orange-brown liquid. Osmolality: 250 mOsm/kg. d 1.01.

Therapeutic Category

Diagnostic aid (MRI contrast agent).

Keywords

Diagnostic Aid (MRI Contrast Agent)