Ultrasmall superparamagnetic iron oxide (USPIO) magnetite nanoparticles covered with low molecular weight dextran T-10; designed for use as an MRI imaging agent to detect metastatic cancer in lymph nodes. Prepn: E. V. Groman et al.,WO 8800060; S. Palmacci, L. Josephson, US 5262176 (1988, 1993 both to Advanced Magnetics). Physical and chemical properties: C. W. Jung, P. Jacobs, Magn. Reson. Imaging 13, 661 (1995); surface properties: C. W. Jung, ibid. 675. Biodistribution study: H. H. Bengele et al., ibid. 12, 433 (1994). Clinical studies of diagnostic use: Y. Anai et al., Radiology 228, 777 (2003); A. G. Rockall et al., J. Clin. Oncol. 23, 2813 (2005). Review of clinical experience: M. G. Harisinghani et al., RadioGraphics 24, 867-878 (2004); of pharmacology and preclinical studies: P. Bourrinet et al., Invest. Radiol. 41, 313 2006.
Diagnostic aid (MRI contrast agent).
Diagnostic Aid (MRI Contrast Agent)