4194. Fluprostenol

Nomenclature

CAS number: 40666-16-8
(5Z)-rel-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid; ICI-81008; Equimate.
C23H29F3O6; mol wt 458.47.
C 60.25%, H 6.38%, F 12.43%, O 20.94%.

Description and references

Potent luteolytic agent related to prostaglandin F2α, q.v.: Dukes, Walpole, Nature 250, 330 (1974). Prepn: Binder et al., Prostaglandins 6, 87 (1974). Induction of estrus and luteolysis in mares: Cooper, Farr, Vet. Rec. 94, 161 (1974); Berwyn-Jones, Irvine, N. Z. Vet. J. 22, 107 (1974).

Chemical structure

Derivative

Sodium salt.

Nomenclature

CAS number: 55028-71-2
ICI-80008.
C23H28F3NaO6; mol wt 480.45.
C 57.50%, H 5.87%, F 11.86%, Na 4.79%, O 19.98%.

Therapeutic Category (Veterinary)

Treatment of infertility in mares.