4261. Fotemustine

Nomenclature

CAS number: 92118-27-9
[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]phosphonic acid diethyl ester; (±)-diethyl [1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate; 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester; S-10036; Muphoran (Servier).
C9H19ClN3O5P; mol wt 315.69.
C 34.24%, H 6.07%, Cl 11.23%, N 13.31%, O 25.34%, P 9.81%.

Description and references

Amino acid-linked nitrosourea alkylating agent. Prepn: G. Lavielle, C. Cudennec, FR 2536075; eidem, US 4567169 (1984, 1986 both to ADIR). Clinical evaluation in advanced cancers: D. Khayat et al., Cancer Res. 47, 6782 (1987); in disseminated malignant melanoma: D. Khayat et al., J. Natl. Cancer Inst. 80, 1407 (1988).

Chemical structure

Properties

mp 85°.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents; Nitrosoureas