4323. Gadobutrol

Nomenclature

CAS number: 138071-82-6
[10-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3)-N1,N4,N7,N10,O1,O4,O7]gadolinium; Gd-DO3A-butrol; Gadovist (Schering AG).
C18H31GdN4O9; mol wt 604.71.
C 35.75%, H 5.17%, Gd 26.00%, N 9.27%, O 23.81%.

Description and references

Neutral, macrocyclic gadolinium chelate. Prepn: J. Platzek et al., EP 448191 (1991 to Schering AG). Physicochemical properties and in vivo imaging studies: H. Vogler et al., Eur. J. Radiol. 21, 1 (1995). Clinical pharmacokinetics: T. Staks et al., Invest. Radiol. 29, 709 (1994). Clinical evaluation of diagnostic use for cerebral metastases: T. J. Vogl et al., Radiologe 35, 508 (1995); for glioblastomas: M. Hartmann et al., Fortschr. Rntgenstr. 164, 119 (1996).

Chemical structure

Properties

Hydrophilic. Osmolality (osmol/kg): 0.57 (0.5 mol/l); 1.39 (1 mol/l). Viscosity (cP): 1.43 (0.5 mol/l); 3.7 (1 mol/l). Partition coefficient (butanol/water): 0.006. LD50 i.v. in mice: 23 mmol/kg (Vogler).

Therapeutic Category

Diagnostic aid (MRI contrast agent).

Keywords

Diagnostic Aid (MRI Contrast Agent)