4324. Gadodiamide

Nomenclature

CAS number: 131410-48-5
[5,8-Bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oato(3)]gadolinium; gadolinium diethylenetriamine pentaacetic acid bismethylamide; Gd-DTPA-BMA; S-041.
C16H26GdN5O8; mol wt 573.66.
C 33.50%, H 4.57%, Gd 27.41%, N 12.21%, O 22.31%.

Description and references

Nonionic, low-osmolar paramagnetic gadolinium chelate complex. Prepn: S. C. Quay, WO 8602841 (1986 to New Salutar); idem, US 4687659 (1987 to Salutar). Pharmacokinetics, hemodynamics and toxicology: E. S. Harpur et al., Invest. Radiol. 28, Suppl. 1, S28 (1993). Clinical pharmacokinetics: M. VanWagoner, D. Worah, ibid. S44. Clinical study of CNS imaging: G. Sze et al., ibid. 28, Suppl. 1, S49 (1993); J. Valk et al., Neuroradiology 35, 173 (1993); of myocardial imaging: M.-C. Dulce et al., Am. J. Roentgenol. 160, 963 (1993). Review of physicochemical properties: C. A. Chang, Invest. Radiol. 28, Suppl. 1, S21-S27 (1993).

Chemical structure

Properties

Osmolality (37°, 0.1M): 111 μmol/kg water. LD50 i.v. in mice: 14 mmol/kg (Chang).

Derivative

Gadodiamide injection.

Nomenclature

CAS number: 131410-51-0
Omniscan (GE Healthcare).
C16H28GdN5O9.C16H26CaN5NaO8; mol wt 1071.15.
C 35.88%, H 5.08%, Gd 14.68%, N 13.08%, O 25.39%, Ca 3.74%, Na 2.15%.

Properties

Osmolality (37°, 0.5M): 789 mOsM/kg water. Viscosity (cP): 2.0 (20°), 1.4 (37°). d20 1.13. Log P (butanol/water): 2.1. LD50 i.v. in mice: 34 mmol/kg (Harpur).

Therapeutic Category

Diagnostic aid (MRI contrast agent).

Keywords

Diagnostic Aid (MRI Contrast Agent)