4362. Ganaxolone

Nomenclature

CAS number: 38398-32-2
(3α,5α)-3-Hydroxy-3-methylpregnan-20-one; CCD-1042.
C22H36O2; mol wt 332.52.
C 79.46%, H 10.91%, O 9.62%.

Description and references

Synthetic analog of the neuroactive steroids known as epalons that allosterically modulate the γ-aminobutyric acid type A (GABAA) receptor. Prepn: M. C. Cook et al., DE 2162555; eidem, US 3953429 (1972, 1976 both to Glaxo); D. J. Hogenkamp et al., J. Med. Chem. 40, 61 (1997). Binding study and anticonvulsant activity: R. B. Carter et al., J. Pharmacol. Exp. Ther. 280, 1284 (1997). Clinical pharmacology: E. P. Monaghan et al., Epilepsia 38, 1026 (1997). Determn in serum by HPLC-MS-MS: K. Ramu et al., J. Chromatogr. B 751, 49 (2001).

Chemical structure

Properties

White crystals from methanol, mp 190-192°. [α]D +103°. Insol in aqueous media.

Therapeutic Category

Anticonvulsant; antimigraine.

Keywords

Anticonvulsant; Antimigraine