5239. Ispronicline

Nomenclature

CAS number: 252870-53-4
(2S,4E)-N-Methyl-5-[5-(1-methylethoxy)-3-pyridinyl]-4-penten-2-amine; RJR-1734; TC-1734.
C14H22N2O; mol wt 234.34.
C 71.75%, H 9.46%, N 11.95%, O 6.83%.

Description and references

Specific α4β2 nicotinic receptor agonist. Prepn: W. S. Caldwell et al., WO 9965876 (1999 to R. J. Reynolds); eidem, US 6958399 (2005 to Targacept). Effect on cortical acetylcholine release in rats: M. C. Obinu et al., Prog. Neuro-Psychopharmacol. Biol. Psychiatry 26, 913 (2002). Review of pharmacology: G. J. Gatto et al., CNS Drug Rev. 10, 147-166 (2004); and clinical experience: H. Geerts, Curr. Opin. Investig. Drugs 7, 60-69 (2006).

Chemical structure

Properties

Colorless oil, bp0.5 90-100°.

Derivative

Hemigalactarate.

Nomenclature

CAS number: 252870-54-5
C28H44N4O2.C6H10O8; mol wt 678.81.
C 60.16%, H 8.02%, N 8.25%, O 23.57%.

Properties

White crystalline powder, mp 140-143°.

Therapeutic Category

Nootropic.

Keywords

Nootropic