5832. Menadoxime

Nomenclature

CAS number: 573-01-3
[[(3-Methyl-4-oxo-1(4H)-naphthalenylidene)amino]oxy]acetic acid ammonium salt; menadione carboxymethoxime ammonium salt; menaphthone carboxymethoxime ammonium salt; carboxymethylmenadione monoxime ammonium salt; Kapilon injectable.
C13H14N2O4; mol wt 262.26.
C 59.54%, H 5.38%, N 10.68%, O 24.40%.

Description and references

Prepn: Holland, GB 621934 (1949 to Glaxo).

Chemical structure

Properties

Crystals from alc. Sol in water. Aq solns are neutral. May be sterilized by autoclaving and stored in ampuls if protected from light. Shows high antihemorrhagic activity.

Derivative

Free acid.
C13H11NO4; mol wt 245.23.
C 63.67%, H 4.52%, N 5.71%, O 26.10%.

Properties

Yellow platelets from alc, mp 162-163°. Forms water-sol salts.

Therapeutic Category

Vitamin (prothrombogenic).

Keywords

Vitamin/Vitamin Source; Vitamin K