5856. Mepindolol

Nomenclature

CAS number: 23694-81-7
1-[(1-Methylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol; 1-(isopropylamino)-3-[(2-methylindol-4-yl)oxy]-2-propanol.
C15H22N2O2; mol wt 262.35.
C 68.67%, H 8.45%, N 10.68%, O 12.20%.

Description and references

β-Adrenergic blocker; the 2-methyl analog of pindolol, q.v. Prepn: F. Troxler, CH 469002 and CH 472404 (both 1969 to Sandoz); F. Seeman et al., Helv. Chim. Acta 54, 2411 (1971). Pharmacokinetics: R. Gugler et al., Arzneim.-Forsch. 25, 1067 (1975). Pharmacodynamics: J. Bonelli et al., Eur. J. Clin. Pharmacol. 15, 1 (1979). Clinical studies: H. M. Beumer et al., Int. J. Clin. Pharmacol. Biopharm. 16, 249 (1978); M. Sukerman et al., Curr. Ther. Res. 25, 384 (1979).

Chemical structure

Properties

Crystals from ethyl acetate, mp 100-102° (Seeman). Also reported as 95-97° (Troxler).

Derivative

Sulfate salt.

Nomenclature

CAS number: 56396-94-2
SH-E-222; Betagon (Schering AG); Corindolan (Schering AG); Mepicor (Corvi).
(C15H22N2O2)2.H2SO4; mol wt 622.77.
C 57.86%, H 7.45%, N 9.00%, O 20.55%, S 5.15%.

Therapeutic Category

Antihypertensive; antianginal.

Keywords

β-Adrenergic Blocker; Antianginal; Antihypertensive; Aryloxypropanolamine Derivatives