5946. Methallibure

Nomenclature

CAS number: 926-93-2
N-Methyl-N′-(1-methyl-2-propenyl)-1,2-hydrazinedicarbothioamide; 1-methyl-6-(1-methylallyl)-2,5-dithiobiurea; N-methylthiocarbamoyl-N′-[(1-methylallyl)thiocarbamoyl]hydrazine; metallibure; ICI-33828; Aimax (Ayerst).
C7H14N4S2; mol wt 218.34.
C 38.51%, H 6.46%, N 25.66%, S 29.37%.

Description and references

Prepn: Paget et al., GB 878177 (1961 to I.C.I.). Inhibition of pituitary gonadotropic function in animals: Paget et al., Nature 192, 1191 (1961). Prevention of fetus nidation when given orally to rats: Harper, J. Reprod. Fertil. 7, 211 (1964).

Chemical structure

Properties

Crystals, dec 198-200°.

Therapeutic Category (Veterinary)

Anterior pituitary activator (for swine).