6136. Methyprylon

Nomenclature

CAS number: 125-64-4
3,3-Diethyl-5-methyl-2,4-piperidinedione; 2,4-dioxo-3,3-diethyl-5-methylpiperidine; 3,3-diethyl-2,4-dioxo-5-methylpiperidine; Noctan; Dimerin; Noludar (Roche).
C10H17NO2; mol wt 183.25.
C 65.54%, H 9.35%, N 7.64%, O 17.46%.

Description and references

Prepn: Frick, Lutz, US 2680116 (1954 to Hoffmann-La Roche). cf. DE 930206 (1953). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 363-382 (1973).

Chemical structure

Properties

Crystals. Bitter taste. mp 74-77°. uv max (alcohol): 295 nm (A1%1cm 2.0). Sol in water, alcohol, benzene, chloroform.

Caution

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Piperidinediones