6174. Mibolerone

Nomenclature

CAS number: 3704-09-4
(7α,17β)-17-Hydroxy-7,17-dimethylestr-4-en-3-one; 7α,17α-dimethyl-19-nortestosterone; U-10997; Cheque.
C20H30O2; mol wt 302.45.
C 79.42%, H 10.00%, O 10.58%.

Description and references

Synthetic anabolic steroid related to testosterone, q.v. Prepn: BE 610385; J. C. Babcock, J. A. Campbell, US 3341557 (1962, 1967 both to Upjohn). Biological properties: J. A. Campbell et al., Steroids 1, 317 (1963). Dissolution and solubility rates: W. E. Hamlin et al., J. Pharm. Sci. 54, 1651 (1965). Pharmacodynamics: J. H. Sokolowski, C. W. Kasson, Am. J. Vet. Res. 39, 837 (1978). Efficacy evaluation in dogs: J. H. Sokolowski, J. Am. Vet. Med. Assoc. 173, 983 (1978).

Chemical structure

Properties

Cryst solid. Soly in deionized water: 0.0454 mg/ml at 37°.

Note

This is a controlled substance (anabolic steroid): 21 CFR, 1308.13, as defined in 1300.01.

Therapeutic Category (Veterinary)

Antigonadotropic used to suppress estrus.