6212. Mitobronitol

Nomenclature

CAS number: 488-41-5
1,6-Dibromo-1,6-dideoxy-d-mannitol; 1,6-dideoxy-1,6-dibromo-d-mannitol; dibromomannitol; DBM; Myebrol (Kyorin); Myelobromol (Enzypharm).
C6H12Br2O4; mol wt 307.97.
C 23.40%, H 3.93%, Br 51.89%, O 20.78%.

Description and references

Cytostatic agent; the first dibromohexitol introduced into clinical use. Manuf: GB 959407 (1964 to Chinoin). Pharmaco-biochemical studies: J. Szabo et al., Neoplasma 20, 13 (1973). Clinical studies: D. F. Chiuten et al., Cancer 47, 442 (1981). Comparative study with busulfan, q.v.: R. T. Silver et al., Cancer 60, 1442 (1987).

Chemical structure

Properties

Crystals from methanol + dichloroethane, mp 176-178°.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents