6214. Mitolactol

Nomenclature

CAS number: 10318-26-0
1,6-Dibromo-1,6-dideoxygalactitol; 1,6-dibromo-1,6-dideoxydulcitol; dibromodulcitol; dibromodulcit; DBD; NSC-104800; Elobromol (Chinoin).
C6H12Br2O4; mol wt 307.97.
C 23.40%, H 3.93%, Br 51.89%, O 20.78%.

Description and references

Diastereoisomer of mitobronitol, q.v., with myelosuppressive effects. Prepn and anticancer activity: NL 6600395; P. Horváth-Lengyel et al., US 3993781 (1966, 1976 both to Chinoin); B. Kellner et al., Nature 213, 402 (1967). Structure-activity correlations: L. Institoris et al., Arzneim.-Forsch. 17, 145 (1967). Pharmacological study: T. H. Corbett et al., Cancer 40, Suppl. 5, 2660 (1977). Metabolism, pharmacokinetics: I. P. Horváth et al., Eur. J. Cancer 15, 337 (1979). Clinical studies: W. Medina, J. M. Kirkwood, Cancer Treat. Rep. 66, 195 (1982); D. C. Tormey et al., Am. J. Clin. Oncol. 5, 33 (1982).

Chemical structure

Properties

Crystals from methanol, aq alc, or aq acetone, mp 187-188° (dec). LD50 in rats (mg/kg): 1400 orally; 470 i.p. (Kellner).

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents