6287. Moxastine

Nomenclature

CAS number: 3572-74-5
2-(1,1-Diphenylethoxy)-N,N-dimethylethanamine; α-methylbenzhydryl 2-dimethylaminoethyl ether; α-methyldiphenhydramine; mephenhydramine; Spofa 325; Alfadryl (Leciva).
C18H23NO; mol wt 269.38.
C 80.26%, H 8.61%, N 5.20%, O 5.94%.

Description and references

Prepn: Protiva et al., Chem. Listy 43, 257 (1949); CS 86516 (1957), C.A. 53, 1261 (1959); Z. Vejdelek et al., Collect. Czech. Chem. Commun. 49, 2649 (1984).

Chemical structure

Properties

bp0.15 129-136°.

Derivative

Hydrochloride.
C18H23NO.HCl; mol wt 305.84.
C 70.69%, H 7.91%, N 4.58%, O 5.23%, Cl 11.59%.

Properties

mp 168°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Aminoalkylethers