6666. Nocardicin(s)
Description and references
Monocyclic β-lactam antibiotics with antimicrobial activity which inhibit bacterial cell wall biosynthesis. Nocardicins A, B, C, D, E, F, G have been identified. All are produced by Nocardia uniformis subsp. tsuyamenensis, A being the most important component. Prodn: H. Aoki et al., DE 2242699 (1973 to Fujisawa), C.A. 78, 134496k (1973); US 3923977 (1975 to Fujisawa). Isoln and characterization of A: H. Aoki et al., J. Antibiot. 29, 492 (1976); of B: M. Kurita et al., ibid. 1243. Nocardicin A has also been produced by Actinosynnema mirum: K. Watanabe et al., ibid. 36, 321 (1983). Structural determination of A and B: M. Hashimoto et al., J. Am. Chem. Soc. 98, 3023 (1976), J. Antibiot. 29, 890 (1976). Isoln, characterization, and structures of C, D, E, F, G: J. Hosoda et al., Agric. Biol. Chem. 41, 2013 (1977). Total synthesis of A: G. A. Koppel et al., J. Am. Chem. Soc. 100, 3933 (1978); W. V. Curran et al., J. Antibiot. 35, 329 (1981); of A and D: T. Kamiya et al., Tetrahedron 1979, 323; of A and B: H. P. Isenring, W. Hofheinz, Tetrahedron 1983, 2591. Biosynthetic studies of A: J. Hosada et al., Agric. Biol. Chem. 41, 2007 (1977); C. A. Townsend et al., J. Am. Chem. Soc. 105, 919 (1983). Series of articles on antimicrobial activity of A: J. Antibiot. 30, 917-944 (1977).
