6667. Nociceptin
Nomenclature
CAS number: 170713-75-4
Orphanin FQ (swine); orphanin FQ; OFQ. C79H129N27O22; mol wt 1809.04.
C 52.45%, H 7.19%, N 20.91%, O 19.46%.
Description and references
Seventeen amino acid neuropeptide identified as the endogenous ligand of the orphan opioid receptor, ORL-1. Shows a wide variety of pharmacological effects. Structurally related to the opioids, but does not bind to opiate receptors. Isoln from rat brain: J.-C. Meunier et al., Nature 377, 532 (1995); from porcine hypothalmus: R. K. Reinscheid et al., Science 270, 792 (1995). Distribution and localization of binding with opioid peptides: S. Schulz et al., NeuroReport 7, 3021 (1996). Binding affinity: I. D. Adapa, L. Toll, Neuropeptides 31, 403 (1997). Review: J.-C. Meunier, Eur. J. Pharmacol. 340, 1-15 (1997). Review of pharmacology and structure-activity: G. Henderson, A. T. McKnight, Trends Pharmacol. Sci. 18, 293-300 (1997).
