6732. Nylidrin

Nomenclature

CAS number: 447-41-6
4-Hydroxy-α-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzenemethanol; p-hydroxy-α-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl alcohol; p-hydroxy-N-(1-methyl-3-phenylpropyl)norephedrine; buphenine; 1-(p-hydroxyphenyl)-2-(1′-methyl-3′-phenylpropylamino)-1-propanol; phenyl-sec-butyl norsuprifen.
C19H25NO2; mol wt 299.41.
C 76.22%, H 8.42%, N 4.68%, O 10.69%.

Description and references

Prepn: FR 968273 (1950 to Troponwerke Dinklage); GB 669574; GB 669575 (1952); Chem. Eng. News 33, 2896 (1955); Külz, Sch"opf, US 2661372; US 2661373 (1953). Pharmacology: T. T. Yen, D. V. Pearson, Res. Commun. Chem. Pathol. Pharmacol. 23, 11 (1979); B. Fichtl, W. Felix, Eur. J. Pharmacol. 65, 333 (1980).

Chemical structure

Properties

Crystals from methanol, mp 111-112°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 849-55-8
SKF-1700-A; Arlidin (USV); Bufedon (Cosmopharma); Buphedrin (Tatsumi); Dilatal; Dilatol (Troponwerke); Dilatropon (Draco); Dilydrin (Medichemie); Opino (Bayropharma); Penitardon (Woelm); Perdilatal (Smith & Nephew); Rudilin (Darby); Rydrin (Kodama); Tocodilydrin (Swiss Pharma); Tocodrin (Medichemie).
C19H25NO2.HCl; mol wt 335.87.
C 67.94%, H 7.80%, N 4.17%, O 9.53%, Cl 10.56%.

Properties

Crystals. Sparingly sol in water; slightly sol in alcohol. Practically insol in ether, chloroform, benzene.

Therapeutic Category

Vasodilator (peripheral).

Keywords

Vasodilator (Peripheral)