6844. Omega-3 Acid Ethyl Esters

Nomenclature

CAS number: 308081-97-2
Omega-3 polyunsaturated fatty acids ethyl esters; Lovaza (Reliant); Omacor (Pronova).

Description and references

Mixture of ethyl esters of long-chain omega-3 fatty acids extracted from fish oil, primarily docosahexaenoic and eicosapentaenoic acids, q.q.v. Purification from crude fish oil: H. Breivik et al., US 5656667 (1997 to Norsk Hydro). Clinical effect on lipid profile in combined hyperlipidemia: L. Calabresi et al., Atherosclerosis 148, 387 (2000). Clinical trial to prevent sudden death following myocardial infarction: A. Macchia et al., Eur. J. Heart Fail. 7, 904 (2005). Clinical effect of combination with simvastatin in persistent hypertriglyceridemia: M. H. Davidson et al., Clin. Ther. 29, 1354 (2007). Review of clinical experience: H. Bays, Am. J. Cardiol. 98, Suppl. 4A, 71i-76i (2006).

Properties

Light yellow liquid with slight fish-like odor. Practically insol in water. Very sol in acetone, dehydrated alcohol, heptane, methanol.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic