7040. Park Nucleotide
Nomenclature
CAS number: 18836-50-5 (l-lysyl form);
120010-32-4
(pimelate form)
UDP-MurNAc-l-Ala-γ-d-Glu-X-d-Ala-d-Ala; stem peptide. Description and references
Glyco-pentapeptide; key intermediate in bacterial cell-wall synthesis. Residue 3 varies from species to species; it is usually l-Lys in Gram positive bacteria and mesodiaminopimelate in Gram negative bacteria. Identification and isolation from Staphylococcus aureus: J. T. Park, J. Biol. Chem. 194, 885 (1952). Total synthesis: S. A. Hitchcock et al., J. Am. Chem. Soc. 120, 1916 (1998); of radioiodinated analog: C. N. Eid et al., J. Labelled Compd. Radiopharm. 41, 705 (1998).
