7163. Perhexiline

Nomenclature

CAS number: 6621-47-2
2-(2,2-Dicyclohexylethyl)piperidine; 1,1-dicyclohexyl-2-(2-piperidyl)ethane; perhexilene.
C19H35N; mol wt 277.49.
C 82.24%, H 12.71%, N 5.05%.

Description and references

Calcium blocking agent. Prepn: GB 1025578 (1966 to Richardson-Merrell), C.A. 65, 2229f (1966). Pharmacology: Hudak et al., J. Pharmacol. Exp. Ther. 173, 371 (1970). Clinical studies: Winsor, Clin. Pharmacol. Ther. 11, 85 (1970). Toxicity study: Causa, Perri, Arzneim.-Forsch. 21, 114 (1971). Series of articles: Postgrad. Med. J. Suppl. 49, 8-132 (1973). Book: Antiarrhythmic Action and the Puzzle of Perhexiline, E. M. Vaughan Williams, Ed. (Academic Press, New York, 1980) 143 pp.

Chemical structure

Derivative

Maleate.

Nomenclature

CAS number: 6724-53-4
Pexid (Sigma).
C19H35N.C4H4O4; mol wt 393.56.
C 70.19%, H 9.99%, N 3.56%, O 16.26%.

Properties

mp 188.5-191°. LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri).

Derivative

Hydrochloride.
C19H35N.HCl; mol wt 313.95.
C 72.69%, H 11.56%, N 4.46%, Cl 11.29%.

Properties

White crystalline powder, mp 243-245.5° (dec).

Therapeutic Category

Vasodilator (coronary); diuretic.

Keywords

Calcium Channel Blocker; Diuretic; Vasodilator (Coronary)