7164. Pericyazine

Nomenclature

CAS number: 2622-26-6
10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile; 2-cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; periciazine; propericiazine; RP-8908; Aolept (Bayer); Neulactil (M & B); Neuleptil (Aventis).
C21H23N3OS; mol wt 365.49.
C 69.01%, H 6.34%, N 11.50%, O 4.38%, S 8.77%.

Description and references

Psychotherapeutic phenothiazine. Prepn: Robert, Jacques, FR 1212031 (1960 to Rh^one-Poulenc). Hypotensive action in dogs: K. P. Singh et al., Indian J. Med. Res. 58, 1467 (1970). GLC determn in human urine: A. P. De Leenheer, J. Pharm. Sci. 63, 389 (1974). Clinical studies in psychiatric patients: U. Spiegelberg, G. Kleu, Arzneim.-Forsch. 17, 159 (1967); J. C. Barker, M. Miller, Br. J. Psychiatry 115, 169 (1969). Toxicity and metabolism: L. Julou et al., Proc. Eur. Soc. Study Drug Toxic. 9, 11 (1968). Toxicity data: Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972). Use in spectrophotometry: H. Gowda et al., Anal. Chem. 55, 1816 (1983); A. T. Gowda et al., Anal. Chim. Acta 154, 347 (1983).

Chemical structure

Properties

Crystals, mp 116-117°. uv max: 232.5, 271.5 nm (log ε 4319, 4503). LD50 orally in rats: 395 mg/kg (Schafer).

Use

Spectrophotometric reagent for palladium and ruthenium.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines