Nomenclature
CAS number: 9002-92-0
α-Dodecyl-ω-hydroxypoly(oxy-1,2-ethanediyl); polyethylene glycol (9) monododecyl ether; dodecyl alcohol polyoxyethylene ether; hydroxypolyethoxydodecane; laureth 9; polyoxyethylene lauryl ether; Aethoxysklerol (Kreussler); Aetoxisclerol (Dexo); Atlas G-4829 (ICI); Hetoxol L-9 (Heterene Chem.).
C12H25(OCH2CH2)nOH.
Description and references
Contains an average of nine ethylene oxide
units and has an average mol wt ≈600. Prepd by reaction of ethylene
oxide and dodecyl alcohol: Pertsemlides, Soehring, Arzneim.-Forsch. 10, 990 (1960).
Toxicology: H. S. Zipf et al., ibid. 7, 162 (1957). Review of clinical experience:
P. M. Goldman, J. Dermatol. Surg. Oncol. 15, 204-209 (1989).
Properties
Sol in water, ethanol, toluene. Miscible with
hot mineral, natural and synthetic oils; with fats and fatty alcohols.
LD50 in mice (mg/kg): 1170 orally, 125 i.v. (Zipf).Use
Solvent; nonionic emulsifier; pharmaceutic aid (surfactant);
spermaticide.
Therapeutic Category
Anesthetic (topical); antipruritic; sclerosing agent.
Keywords
Anesthetic (Local); Antipruritic; Sclerosing Agent