Description and references

Prepn: J. Keck, Z. Naturforsch. 18b, 177 (1963); A. Bonati, E. Bombardelli, Farmaco Ed. Sci. 18, 851 (1963); J. Keck, DE 1154120 (1963 to Thomae); idem, US 3414577 (1968 to Boehringer, Ing.). Pharmacology: R. Koch, Arzneim.-Forsch. 22, 2079 (1972); H. M. Mertens et al., ibid. 23, 642 (1973); K.-W. Diederich, D. Boyksen, ibid. 1302. Toxicology: G. Von Philipsborn, B. Stalder, ibid. 22, 2085 (1972). Pharmacokinetics: A. T. Trompler et al., ibid. 33, 436 (1983). Mechanism of action: H. Langenfeld et al., J. Cardiovasc. Pharmacol. 15, 338 (1990). GC/MS determn in urine: H. H. Maurer, Arch. Toxicol. 64, 218 (1990). Clinical comparison with tocainide, q.v.: B. Schwartzkopff et al., Arzneim.-Forsch. 33, 153 (1983).

Derivative