7701. Pradofloxacin
Nomenclature
CAS number: 195532-12-8
8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid; 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic
acid. C21H21FN4O3; mol wt 396.41.
C 63.63%, H 5.34%, F 4.79%, N 14.13%, O 12.11%.
Description and references
Cyanofluorinated quinoline antibiotic. Prepn: S. Bartel et al., WO 9731001; eidem, US 6323213 (1997, 2001 both to Bayer). LC/MS/MS determn in biological fluids: R. Krebber, J. Vet. Pharmacol. Ther. 26, Suppl 1, 102 (2003). Bioavailability: M. A. Bregante et al., ibid. 87; K. Fraatz et al., ibid. 88. Clinical trial in dogs in comparison with amoxicillin and clavulanic acid, q.q.v.: B. Stephan et al., ibid. 217.
