7762. Procodazole

Nomenclature

CAS number: 23249-97-0
1H-Benzimidazole-2-propanoic acid; β-(2-benzimidazolyl)propionic acid; 2-(2-carboxyethyl)benzimidazole; propazol; AL-1241; Estimulocel (Alonga).
C10H10N2O2; mol wt 190.20.
C 63.15%, H 5.30%, N 14.73%, O 16.82%.

Description and references

Non-specific, active immunoprotective agent against viral and bacterial infections. Prepn: J. Maier, Ann. 327, 17 (1903); R. Meyers, H. Lüders, ibid. 415, 29 (1918); B. Chatterjee, J. Chem. Soc. 1929, 2966; ES 407882 (1972 to Lafarquim). Pharmacological studies: C. Fernández et al., Rev. Clin. Esp. 135, 539 (1974); eidem, ibid. 141, 51 (1976). Clinical studies: M. Pérez Tascon, J. M. Monturio, Med. Klin. 181, 78 (1976).

Chemical structure

Properties

Silky white needles from water, mp 228° (dec). Sol in alc, warm water. Practically insol in ether, benzene. The water soln is extremely sweet-tasting.

Therapeutic Category

Immunopotentiator (non-specific).

Keywords

Immunomodulator