7871. Propyphenazone

Nomenclature

CAS number: 479-92-5
1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one; 4-isopropylantipyrine; 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 2,3-dimethyl-1-phenyl-4-isopropylpyrazolone; isopropylphenazone; Budirol (Fher); Causyth (Inverni); Eufibron (Berlin-Chemie); Isoprochin P (Merckle).
C14H18N2O; mol wt 230.31.
C 73.01%, H 7.88%, N 12.16%, O 6.95%.

Description and references

Prepn: Stenz, US 1972036 (1934 to Hoffmann-La Roche); Sawa, J. Pharm. Soc. Jpn. 57, 953 (1937), C.A. 32, 2533 (1938).

Chemical structure

Properties

Slightly bitter crystals, mp 103°. Readily sol in alcohol, ether. Soly in water: 0.24 g/100 ml at 16.5°.

Therapeutic Category

Analgesic; antipyretic; anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Pyrazolones; Antipyretic; Analgesic; Non-opioids; Pyrazolones