7923. Psicofuranine
Nomenclature
CAS number: 1874-54-0
9-β-d-Psicofuranosyl-9H-purin-6-amine; 9β-d-psicofuranosyladenine; 6-amino-9-d-psicofuranosylpurine; angustmycin C; U-9586. C11H15N5O5; mol wt 297.27.
C 44.44%, H 5.09%, N 23.56%, O 26.91%.
Description and references
Nucleoside antibiotic produced by Streptomyces hygroscopicus var. decoyicus: Eble et al., Antibiot. Chemother. 9, 419 (1959); Yüntsen, J. Antibiot. 11A, 244 (1958); Eble, Lewis, US 3020274 (1962 to Upjohn). Antibacterial and antitumor activity: N. Tanaka et al., J. Antibiot. 14A, 98 (1961). Structure: Schroeder, Hoeksema, J. Am. Chem. Soc. 81, 1767 (1959); Garrett, ibid. 82, 827 (1960). Synthesis: Farkas, Sorm, Collect. Czech. Chem. Commun. 28, 882 (1963); L. A. Aleksandrova, F. W. Lichtenthaler, Nucleic Acids Symp. Ser. 9, 263 (1981). Biosynthesis: Sugimori, Suhadolnik, J. Am. Chem. Soc. 87, 1136 (1965). Inhibits the conversion of xanthosine-5′-phosphate to guanosine-5′-phosphate: Slechta, Biochem. Pharmacol. 5, 96 (1960).
