7971. 3-Pyridineacetic Acid

Nomenclature

CAS number: 501-81-5
Lioxone; 3PAA; Minedil (Formenti).
C7H7NO2; mol wt 137.14.
C 61.31%, H 5.14%, N 10.21%, O 23.33%.

Description and references

Metabolite of nicotine, q.v. Prepn: K. Miescher, H. K"agi, Helv. Chim. Acta 24, 1471 (1941); S. Carboni, Gazz. Chim. Ital. 85, 1194 (1955). Manuf. process: M. Hartmann et al., US 2408020 (1946 to Ciba). Pharmacology: E. Ginoulhiac, L. T. Tenconi, Minerva Med. 51, 1166 (1960). Clinical evaluation as hypocholesteremic: F. Pupita, ibid. 1140. Thermal and photodecarboxylation: F. R. Stermitz, W. H. Huang, J. Am. Chem. Soc. 93, 3427 (1971). Determn in biological fluids by HPLC: G. A. Kyerematen et al., J. Chromatogr. 419, 191 (1987); by thermospray LC-MS: K. T. McManus et al., J. Chromatogr. Sci. 28, 510 (1990).

Chemical structure

Properties

Crystals from ethyl acetate or alcohol, mp 144°.

Note

Often confused with homonicotinic acid, (4-methyl-3-pyridinecarboxylic acid), in early literature.

Therapeutic Category

Antilipemic.