7972. Pyridine 1-Oxide

Nomenclature

CAS number: 694-59-7
Pyridine N-oxide.
C5H5NO; mol wt 95.10.
C 63.15%, H 5.30%, N 14.73%, O 16.82%.

Description and references

Prepd industrially by heating pyridine in glacial acetic acid at 80° with 30% hydrogen peroxide. The acid is neutralized and the oxide recovered by distillation: Katritzky et al., J. Chem. Soc. 1957, 1769. Laboratory procedure using peracetic acid: H. S. Mosher et al., Org. Synth. coll. vol. IV, 828 (1963).

Chemical structure

Properties

Deliquescent crystals, mp 66°; bp1.0 100-105°.

Derivative

Hydrochloride.
C5H5NO.HCl; mol wt 131.56.
C 45.65%, H 4.60%, N 10.65%, O 12.16%, Cl 26.95%.

Properties

Crystals from isopropanol, mp 179.5-181°.

Use

Synthetic intermediate.