7996. Pyritinol

Nomenclature

CAS number: 1098-97-1
3,3′-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol]; bis(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) disulfide; bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] disulfide; dipyridoxolyldisulfide; pyridoxine-5-disulfide; pyrithioxin.
C16H20N2O4S2; mol wt 368.47.
C 52.15%, H 5.47%, N 7.60%, O 17.37%, S 17.40%.

Description and references

Prepn: Zima, Schorre, US 3010966 (1961 to E. Merck); Iwanami et al., Bitamin 36, 122 (1967); J. Vitaminol. 14, 321, 326 (1968). HPLC determn in urine: K. Kitao et al., Chem. Pharm. Bull. 25, 1335 (1977). Pharmacokinetics and metabolism: Darge et al., Arzneim.-Forsch. 19, 5, 9, (1969); Nowak, Schorre, ibid. 11. Clinical trial in dementia: S. Hoyer et al., ibid. 27, 671 (1977); A. J. Cooper, R. V. Magnus, Pharmatherapeutica 2, 317 (1980); in cerebrovascular disorders: Y. Tazaki et al., J. Int. Med. Res. 8, 118 (1980).

Chemical structure

Properties

Crystals, mp 218-220°.

Derivative

Dihydrochloride monohydrate.

Nomenclature

Biocefalin (Benvegna); Bonifen (Merck KGaA); Enbol (Chugai); Encephabol (Merck KGaA); Enerbol (Polfa); Epocan (Merck KGaA); Life (SIT).
C16H20N2O4S2.2HCl.H2O; mol wt 459.41.
C 41.83%, H 5.27%, N 6.10%, O 17.41%, S 13.96%, Cl 15.43%.

Properties

mp 184°. Note: Has no vitamin B6 activity.

Therapeutic Category

Nootropic.

Keywords

Nootropic