8102. Ramifenazone

Nomenclature

CAS number: 3615-24-5
1,2-Dihydro-1,5-dimethyl-4-[(1-methylethyl)amino]-2-phenyl-3H-pyrazol-3-one; 4-isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-isopropylaminoantipyrine; isopropylaminophenazone; isopyrin.
C14H19N3O; mol wt 245.32.
C 68.54%, H 7.81%, N 17.13%, O 6.52%.

Description and references

Prepn: E. Skita, W. Stühmer, DE 930328; DE 932677 (both 1955), C.A. 52, 16372i, 20200h (1958). Acute toxicity: E. Tubaro et al., Arzneim.-Forsch. 20, 1024 (1970). Clinical evaluation of combination with phenylbutazone, q.v., in migraine: W. Sacks, S. Afr. Med. J. 58, 444 (1980).

Chemical structure

Properties

Crystals from acetone + glacial acetic acid, mp 80°. LD50 in mice (mg/kg): 843 i.p.; 1070 orally (Tubaro).

Derivative

Hydrochloride monohydrate.
C14H19N3O.HCl.H2O; mol wt 299.80.
C 56.09%, H 7.40%, N 14.02%, O 10.67%, Cl 11.83%.

Derivative

Mixture with phenylbutazone.

Nomenclature

CAS number: 76120-72-4
Tomanol (Byk Gulden).

Therapeutic Category

Analgesic, antipyretic, anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Pyrazolones; Antipyretic; Analgesic; Non-opioids; Pyrazolones