Description and references

Selective noradrenaline reuptake inhibitor. Prepn: P. Melloni et al., DE 2901032; eidem, US 4229449 (1979, 1980 both to Farmitalia Carlo Erba); eidem et al., Eur. J. Med. Chem. - Chim. Ther. 19, 235 (1984). Configuration: P. Melloni et al., Tetrahedron 41, 1393 (1985). HPLC determn of enantiomers in plasma: E. Frigerio et al., J. Chromatogr. A 660, 351 (1994). Metabolism: G. Cocchiara et al., Eur. J. Drug Metab. Pharmacokinet. 16, 231 (1991). Stereoselective kinetics: M. S. Benedetti et al., Chirality 7, 285 (1995). Clinical pharmacokinetics: C. Pellizzoni et al., Biopharm. Drug Dispos. 17, 623 (1996). Clinical trial in depression and social phobia: S. A. Montgomery, J. Psychopharmacol. 11, Suppl., S9 (1997); A. Dubini et al., ibid. S17.

Properties

Derivative